What is the Difference Between Aceclofenac and Diclofenac?

Aceclofenac and diclofenac are both nonsteroidal anti-inflammatory drugs (NSAIDs) used for the treatment of pain and inflammation, but they have some differences in their mechanisms of action and side effect profiles.

Aceclofenac:

Aceclofenac is an orally administered phenylacetic acid derivative with effects on a variety of inflammatory mediators.
It is considered to have better gastrointestinal tolerability than diclofenac due to its predominant cyclooxygenase-2 (COX-2) inhibition.
Aceclofenac has a rapid onset of action and a longer duration of action compared to diclofenac.
In a study comparing the two drugs for postoperative pain relief after third molar surgery, aceclofenac demonstrated a superior tolerability profile and better patient compliance.

Diclofenac:

Diclofenac is a potent inhibitor of both COX-1 and COX-2, reducing the synthesis of prostaglandins, prostacyclin, and thromboxane products.
It is associated with adverse effects such as nausea, epigastric pain, peptic ulcer, maculopapular rash, and fixed drug eruptions.
In a study comparing the two drugs for postoperative pain relief after composite resection for oral cancer, the pain relief was better with diclofenac at 48 hours but similar to aceclofenac at 72 hours.

In summary, aceclofenac and diclofenac are both effective in managing pain and inflammation, but they have differences in their mechanisms of action and side effect profiles. Aceclofenac has a more rapid onset of action and a longer duration of action compared to diclofenac, while also demonstrating better gastrointestinal tolerability. However, individual responses to these medications may vary, and it is essential to consult a healthcare professional for personalized treatment recommendations.