What is the Difference Between Aqueous and Non-aqueous Titration?

The main difference between aqueous and non-aqueous titration lies in the solvent used to dissolve the analyte samples. In aqueous titration, water is used as the solvent, while non-aqueous titration utilizes organic solvents for this purpose.

Aqueous Titration:

• Uses water as the solvent for dissolving the analyte.
• Suitable for strong acids and bases, as well as some weak acids and bases.
• Shows sharp end points with internal indicators.

Non-aqueous Titration:

• Utilizes organic solvents for dissolving the sample.
• Suitable for very weak acids and very weak bases, as well as hydrophobic compounds.
• Provides a solvent in which organic compounds are soluble.

Some advantages of non-aqueous titration include its use for determining the purity of assays, the concentration of hydrophobic compounds, and in pharmacopoeial assays. However, there are also some disadvantages, such as the need for temperature corrections, the instability of non-aqueous solvents compared to aqueous solvents, and the requirement for calibration after every use.

Comparative Table: Aqueous vs Non-aqueous Titration

Here is a table summarizing the differences between aqueous and non-aqueous titration:

Aqueous titration uses water as the solvent to dissolve the analyte, while non-aqueous titration uses organic solvents instead of water. Non-aqueous titration is particularly useful for determining the concentration of weak acids, weak bases, and organic substances, as it provides sharp and accurate endpoints.