What is the Difference Between Calciferol and Cholecalciferol?

Calciferol and cholecalciferol are two forms of vitamin D, which is an essential nutrient for the human body. The main differences between them are their sources andStructural differences between calciferol (vitamin D2) and cholecalciferol (vitamin D3) are present in their side chains. The side chain of D2 contains a double bond between carbons 22 and 23, and a methyl group on carbon 24.

• Calciferol (Vitamin D2): This form of vitamin D is derived from plant sources, specifically from exposing ergosterol found in yeast to ultraviolet light. It is produced by invertebrates, like fungus and plants, when exposed to the sun.
• Cholecalciferol (Vitamin D3): This form of vitamin D is derived from animal sources, specifically from exposing lanolin found in sheep to ultraviolet light. It is made in the skin of all vertebrates when exposed to sunlight.

Both calciferol and cholecalciferol are absorbed well from the small intestine and work by increasing the amount of calcium absorbed by the body. They are taken in oral form to treat numerous diseases, including deficiencies and bone-related conditions. Research shows that cholecalciferol is more effective in raising and maintaining vitamin D levels in the body compared to calciferol.

Comparative Table: Calciferol vs Cholecalciferol

Calciferol and cholecalciferol are both forms of vitamin D, but they have some differences in their sources, composition, and effects. Here is a table summarizing the differences between calciferol and cholecalciferol:

In summary, calciferol is primarily derived from ergocalciferol (D2) and is less effective at raising vitamin D levels compared to cholecalciferol, which is derived from both plant and animal sources and is more effective at raising vitamin D levels.