What is the Difference Between Cubicin and Cubicin RF?
🆚 Go to Comparative Table 🆚Cubicin and Cubicin RF are both antibacterial injectables indicated for the treatment of complicated skin and skin structure infections, as well as Staphylococcus aureus bloodstream infections, including those with right-sided infective endocarditis. The major differences between Cubicin and Cubicin RF are related to reconstitution and storage properties:
- Storage: Cubicin RF can be stored at both room temperature and refrigerated temperatures, while Cubicin requires refrigerated storage.
- Reconstitution: Cubicin requires 0.9% sodium chloride as a diluent for reconstitution, whereas Cubicin RF uses sterile or bacteriostatic water.
- In-use Shelf Life: Once reconstituted with sterile water for injection, Cubicin RF vials have an in-use shelf life at room temperature for 1 day and 3 days if refrigerated. If reconstituted with bacteriostatic water for injection, Cubicin RF vials have an in-use shelf life at room temperature for 2 days and 3 days if refrigerated.
Both Cubicin and Cubicin RF are available in a 500 mg per vial strength. The active ingredient in both formulations is the same, but the formulations themselves are not identical.
Comparative Table: Cubicin vs Cubicin RF
Cubicin and Cubicin RF are both formulations of the antibiotic daptomycin, but they differ in storage properties and reconstitution. Here is a table summarizing the differences between Cubicin and Cubicin RF:
Property | Cubicin | Cubicin RF |
---|---|---|
Storage | Requires refrigeration (2°C - 8°C) | Can be stored at room temperature (20°C - 25°C) or refrigerated temperatures |
Reconstitution | Requires reconstitution in 0.9% sodium chloride | Can be reconstituted with either Sterile Water for Injection or 0.9% sodium chloride |
Diluent for Vial Reconstitution | 0.9% sodium chloride | 0.9% sodium chloride or Sterile Water for Injection |
Both Cubicin and Cubicin RF are used to treat complicated skin and skin structure infections (cSSSI) and Staphylococcus aureus bloodstream infections (bacteremia), including those with right-sided infective endocarditis in adult patients. However, Cubicin RF has improved storage and reconstitution properties compared to the original Cubicin formulation.
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