What is the Difference Between DCC and EDC?

The key difference between DCC (N,N′-Dicyclohexylcarbodiimide) and EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide) is that DCC is a cyclic compound, while EDC is an aliphatic compound. Both DCC and EDC are organic compounds used as coupling agents in various chemical reactions.

DCC is insoluble in water, whereas EDC is water-soluble. In the coupling of amino acids during artificial protein synthesis and protein crosslinking to nucleic acids, DCC is used. EDC, on the other hand, has become the most popular carbodiimide used as a condensing agent between NH2 and COOH groups. The urea byproduct of EDC is water-soluble and easily removed by extraction. EDC is used in a wide range of solvents under mild conditions, such as water, DCM, THF, and DMF.

In summary, DCC and EDC are both carbodiimides used in chemical reactions, but they differ in their structure (cyclic vs. aliphatic), solubility in water, and specific applications.

Comparative Table: DCC vs EDC

It appears that there is a misunderstanding in the question, as DCC and EDC are organic compounds used in different applications, while the search results provided are related to data capture methods in clinical research. To clarify, DCC stands for N,N′-Dicyclohexylcarbodiimide, and EDC stands for 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide.

Here is a table comparing the differences between DCC and EDC:

Please note that the information provided is based on the organic compounds DCC and EDC, not the data capture methods in clinical research.