What is the Difference Between EGFR and HER2?
🆚 Go to Comparative Table 🆚The search results provided do not directly address the difference between EGFR and HER2. However, I can provide the information based on my existing knowledge.
EGFR (Epidermal Growth Factor Receptor) and HER2 (Human Epidermal Receptor 2) are both members of the ErbB family of receptor tyrosine kinases, which play a role in regulating cell growth and differentiation. The key differences between EGFR and HER2 are:
- Activation mechanism: EGFR activates directly through binding to its ligands, such as TGF-α, while HER2 requires heterodimerization with another ErbB family member, such as EGFR, to activate.
- Receptor proteins: EGFR is the first discovered member of the ErbB family, and its gene is located on human chromosome 7. In contrast, HER2 is the second member of the ErbB family, and its gene is a proto-oncogene located on the long arm of human chromosome 17.
Both EGFR and HER2 are involved in the development and progression of certain cancers. Amplification or over-expression of HER2 is associated with the development and progression of certain types of cancer, and targeted therapies have been developed to inhibit HER2 activity in these cases.
Comparative Table: EGFR vs HER2
It seems that there has been a misunderstanding, as EGFR and HER2 are not related to hydrogen engines or EGR systems. EGFR and HER2 are actually proteins involved in cell signaling pathways in biology. EGFR (Epidermal Growth Factor Receptor) is a receptor tyrosine kinase involved in the regulation of cell growth, proliferation, and differentiation. HER2 (Human Epidermal Growth Factor Receptor 2) is also a receptor tyrosine kinase and is a member of the EGFR family. Here is a table summarizing the differences between EGFR and HER2:
| EGFR | HER2 |
|---|---|
| Members of the EGFR family of receptor tyrosine kinases | Members of the EGFR family of receptor tyrosine kinases |
| Functions in cell growth, proliferation, and differentiation | Involved in cell signaling pathways |
| Amplification or mutation of EGFR is associated with certain cancers | Amplification or mutation of HER2 is associated with certain cancers |
Please note that this information is based on the biological context of EGFR and HER2 and not related to hydrogen engines or EGR systems.
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