What is the Difference Between Escitalopram and Citalopram?

Escitalopram and citalopram are both selective serotonin reuptake inhibitors (SSRIs) used to treat depression, but they have some differences and similarities.

Similarities:

• Both medications are FDA-approved to treat major depressive disorder.
• Lexapro (escitalopram) is also approved to treat generalized anxiety disorder.
• Both are available in tablet and liquid forms.
• They have similar side effects and interact with other drugs in similar ways.

Differences:

• Citalopram (Celexa) is a mixture of two stereoisomers: R-citalopram and S-citalopram. Escitalopram (Lexapro) contains only one isomer, S-citalopram.
• The equivalent dose of Lexapro is approximately half of that of Celexa. Therefore, the dosing range of Lexapro is 10-20 mg/day, while the dosing range for Celexa is 20-40 mg/day.
• Lexapro has been approved by the FDA for the treatment of generalized anxiety disorder, while Celexa has not.
• A study has shown that escitalopram has better efficacy in treating severe major depressive disorder compared to citalopram.

Both medications have similar safety profiles and are generally well-tolerated. Your mental state may unexpectedly change while taking these medications, and you could have suicidal thoughts as you start your prescription or when your dose goes up or down. It is essential to discuss your health conditions and concerns with your doctor before taking these medications.

Comparative Table: Escitalopram vs Citalopram

Escitalopram and citalopram are both selective serotonin reuptake inhibitors (SSRIs) used to treat depression, but they have some differences. Here is a table summarizing their differences:

Escitalopram is the S-enantiomer of citalopram, which is a mixture of S- and R-enantiomers. Due to this difference, escitalopram dosages are approximately half of those for citalopram. There is increasing evidence suggesting that escitalopram is more clinically effective than citalopram. Additionally, escitalopram is approved to treat Generalized Anxiety Disorder, while citalopram is not.