What is the Difference Between Ferrous Sulfate and Iron Glycinate?

Ferrous sulfate and iron glycinate are both iron supplements used to treat iron deficiency anemia, but they have some differences in terms of absorption, bioavailability, and side effects.

Ferrous Sulfate:

• Contains 20% elemental iron by weight.
• Less expensive and more commonly used in supplementation programs.
• Has side effects such as nausea, vomiting, stomach pains, and constipation.

Iron Glycinate:

• Also known as ferrous bis-glycinate chelate.
• Contains a lower percentage of elemental iron by weight compared to ferrous sulfate.
• Has increased bioavailability and is considered less toxic than ferrous sulfate [1, 4].
• Causes fewer side effects, mainly gastrointestinal symptoms.

Studies have shown that ferrous sulfate is more effective than iron glycinate chelate in treating iron deficiency anemia in certain populations, such as gastrectomized patients. However, iron glycinate chelate has been proposed as an alternative to ferrous sulfate due to its increased bioavailability and lower toxicity [1, 4]. The choice between the two supplements may depend on individual factors, such as the severity of anemia, the patient's overall health, and the desired therapeutic outcome.

Comparative Table: Ferrous Sulfate vs Iron Glycinate

Ferrous sulfate and iron glycinate are both iron supplements used to prevent low levels of iron in the blood, but they have different properties and side effects. Here is a table comparing the two:

In summary, ferrous sulfate is a less expensive iron supplement with poor bioavailability and more side effects, while iron glycinate is a more bioavailable and less toxic alternative with fewer side effects.