What is the Difference Between Hydroxyzine HCL and Hydroxyzine Pamoate?

Hydroxyzine HCl and hydroxyzine pamoate are two versions of the same medication, which is an antihistamine with anticholinergic (drying) and sedative properties. They are used to treat various conditions, including anxiety, itching caused by allergies, and as a sedative when used as premedication to or following general anesthesia. The main differences between the two are:

• Form: Hydroxyzine HCl is available as tablets, syrup, and solution for intramuscular injection, while hydroxyzine pamoate is only available in capsule form.
• Brand Names: Hydroxyzine HCl is commonly known as Atarax, while hydroxyzine pamoate is commonly known as Vistaril.
• Cost: Hydroxyzine HCl tablets and hydroxyzine pamoate capsules vary significantly in price, with hydroxyzine pamoate capsules generally being more expensive.

Despite these differences, both hydroxyzine HCl and hydroxyzine pamoate have the same mechanisms of action, dosing recommendations, and labeled indications. There is no evidence to suggest that one salt form has advantages over the other, and the choice between the two is often based on factors such as patient preference, cost, and availability.

Comparative Table: Hydroxyzine HCL vs Hydroxyzine Pamoate

Hydroxyzine HCL and Hydroxyzine Pamoate are both antihistamine medications used to treat itching caused by allergies, anxiety, and tension, as well as to help patients feel sleepy or relaxed before surgery. They work by blocking histamine, which is produced by the body during an allergic reaction. However, there are some differences between the two:

Both Hydroxyzine HCL and Hydroxyzine Pamoate have the same mechanisms of action, dosing recommendations, and labeled indications. They are primarily used to manage itching due to allergic conditions, anxiety, and as a sedative when used as premedication or following general anesthesia. Despite their differing chemical structures and therapeutic effects, they can sometimes be combined for specific therapeutic benefits, such as managing severe allergic reactions or treating anxiety disorders, but only under the close supervision of a healthcare professional.