What is the Difference Between L Methylfolate and Folic Acid?

L-methylfolate and folic acid are both forms of vitamin B9, but they differ in their structure, absorption, and bioavailability. Here are the main differences between L-methylfolate and folic acid:

1. Natural versus synthetic: L-methylfolate is a natural form of folate found in foods, while folic acid is a synthetic form of the vitamin.
2. Absorption and bioavailability: L-methylfolate is well absorbed and its bioavailability is not affected by metabolic defects. Folic acid, on the other hand, requires additional conversion in the body before it can be used, which may be less efficient for some individuals, particularly those with the MTHFR gene mutation.
3. Methyl donor: L-methylfolate serves as a methyl donor for DNA and RNA assembly, which is important for cellular functions. Folic acid does not have this function.
4. Masking B12 deficiency: Folic acid can mask a vitamin B12 deficiency by preventing megaloblastic anemia, whereas L-methylfolate does not have this effect.
5. Prenatal vitamins: Prenatal vitamins may contain either folic acid or L-methylfolate as the source of folate. L-methylfolate is considered a better option for people with the MTHFR gene mutation, as it bypasses the defective enzyme and provides the body with active folate that it can use.

In summary, L-methylfolate is a more natural and bioavailable form of folate compared to folic acid. It is better absorbed and does not mask B12 deficiencies. L-methylfolate is particularly beneficial for individuals with the MTHFR gene mutation, who may have difficulty converting folic acid into the active form of folate.

Comparative Table: L Methylfolate vs Folic Acid

Here is a table comparing the differences between L-methylfolate and folic acid:

L-methylfolate is the active form of folate inside the body, while folic acid is a synthetic form of vitamin B9. L-methylfolate is highly bioavailable, meaning it can be easily digested and utilized by the body. On the other hand, folic acid has lower bioavailability because it needs to be converted into the active form (L-methylfolate) before it can be used by the body. People with the MTHFR gene mutation may have difficulty converting folic acid into the active form, making L-methylfolate a more effective option for them. Folic acid is known to cause side effects when taken daily for extended periods, while L-methylfolate does not appear to cause such side effects.