What is the Difference Between Ligase and Lyase?
🆚 Go to Comparative Table 🆚Ligases and lyases are two types of enzymes that perform different functions in biochemical reactions:
Ligases:
- Bind two molecules together by forming new bonds.
- Involved in hydrolytic reactions.
- Require energy input from ATP or another nucleotide.
- Sometimes called synthetases.
Lyases:
- Catalyze the reactions involving the breaking of bonds.
- Involved in elimination reactions.
- Catalyze the addition of functional groups to double bonds or the formation of double bonds via the removal of functional groups.
- Do not require ATP to catalyze their reactions.
In summary, ligases are enzymes that join two molecules together, while lyases are enzymes that break bonds or add functional groups to double bonds.
Comparative Table: Ligase vs Lyase
The main difference between ligases and lyases lies in the type of chemical bonds they are involved in forming or breaking. Here is a table comparing the two types of enzymes:
Ligase | Lyase |
---|---|
Catalyzes the formation of chemical bonds between different components | Catalyzes the breaking of various chemical bonds, often forming a new double bond or a new ring structure |
Involved in hydrolysis reactions | Involved in elimination reactions |
Acts on two reactants at a time | Acts on a single substrate in the reaction |
Examples: DNA ligase, RNA ligase | Examples: argininosuccinate lyase, enolase |
Ligases are enzymes that bring about ligation of DNA or another substance, causing bond formations between different components. They act through hydrolysis reactions and require ATP for their reactions. On the other hand, lyases are enzymes that catalyze the breaking of various chemical bonds by means other than hydrolysis and oxidation, often forming a new double bond or a new ring structure. They act through elimination reactions and typically act on a single substrate in the reaction.
- Lyases vs Transferases
- DNA Ligase vs DNA Polymerase
- Hydrolase vs Transferase
- Lysozyme vs Lysosome
- Phosphorylase vs Phosphatase
- Isomerase vs Mutase Enzyme
- T4 DNA Ligase vs E Coli DNA Ligase
- Catalyst vs Enzyme
- Lysine vs L-lysine
- Lipase vs Amylase
- Lactose vs Lactase
- DNA Polymerase vs RNA Polymerase
- Lytic vs Lysogenic
- Endonuclease vs Exonuclease
- Oxidases vs Oxygenases
- Polymerase vs Primase
- Homolysis vs Heterolysis
- Esterase vs Lipase
- Kinase vs Phosphorylase