What is the Difference Between THF and Dioxane?
🆚 Go to Comparative Table 🆚Tetrahydrofuran (THF) and dioxane are both organic solvents, but they have different properties and structures. The main differences between THF and dioxane are:
- Structure: THF molecules contain one oxygen atom as a member of the ring structure, while dioxane molecules contain two oxygen atoms in the ring structure.
- Toxicity: THF is moderately toxic, with a threshold limit in air of 200 ppm, and can form explosive mixtures with air in concentrations between 1.8 and 11.8%. Dioxane is more toxic, with a threshold limit in air of 100 ppm, and can also be absorbed through the skin.
- Basicity: THF is more basic than dioxane, with basicity orders found as THF > dioxane.
- Boiling and Freezing Points: THF has a lower boiling temperature (66 K) and a higher freezing temperature (273.15 K) compared to dioxane, which has a boiling temperature of 101.32 K and a freezing temperature of 11.80 K.
- Polarity: THF is classified as a moderately polar solvent, while dioxane is less polar.
Both solvents are used in various applications, such as analytical samples, high energy density batteries, and as components in mobile phases for reversed-phase liquid chromatography.
Comparative Table: THF vs Dioxane
Here is a table comparing the differences between tetrahydrofuran (THF) and dioxane:
Property | THF | Dioxane |
---|---|---|
Chemical Formula | C4H8O | C4H8O2 |
Oxygen Atoms | 1 | 2 |
Polarity | Moderately polar | Moderately polar |
Solubility | Completely miscible with water and many organic solvents | Completely miscible with water and many organic solvents |
Boiling Point (101.325 kPa, 1 atm) | 66 K | 101.32 K |
Freezing Point | -108.5 K | -273.15 K (estimated from literature value of -123°C) |
Rotational Conformations | None | Exists in chair and boat conformations |
THF and dioxane are both organic solvents used extensively in organometallic chemistry and other applications. They have similar polarities and are completely miscible with water and many organic solvents. The key difference between THF and dioxane is the number of oxygen atoms in their molecular structures, with THF containing one oxygen atom and dioxane containing two oxygen atoms.
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