What is the Difference Between TIBC and UIBC?

The difference between total iron-binding capacity (TIBC) and unsaturated iron-binding capacity (UIBC) lies in their measurements and purpose. Both tests are used to assess the amount of iron in the blood and can help diagnose iron deficiency or overload-related diseases.

TIBC measures the total capacity of the blood to bind and transport iron. It is typically the sum of total serum iron and UIBC. The normal range for TIBC is 240 mcg/dL to 450 mcg/dL. TIBC is increased in patients with iron-deficiency anemia, where a transferrin saturation of 15% or less is noted.

UIBC, on the other hand, measures the reserve capacity of transferrin, or the portion not yet saturated with iron. The sum of UIBC and the plasma iron is the total iron-binding capacity (TIBC). UIBC is decreased in patients with iron-deficiency anemia.

In summary:

• TIBC measures the total capacity of the blood to bind and transport iron, including both serum iron and UIBC.
• UIBC measures the reserve capacity of transferrin, or the portion not yet saturated with iron.

Comparative Table: TIBC vs UIBC

The key difference between TIBC (Total Iron Binding Capacity) and UIBC (Unsaturated Iron Binding Capacity) is that TIBC measures the total capacity of the blood to bind and transport iron, while UIBC measures how much transferrin is not yet bound to iron. Both tests are used to assess iron status and can help diagnose iron deficiency or overload-related diseases. Here is a table summarizing the differences between TIBC and UIBC:

Both tests can be used to detect iron deficiency or overload-related diseases and may cause side effects, such as slight tenderness or bruising at the site of blood draw.