What is the Difference Between Lung Cancer and Mesothelioma?

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Lung cancer and mesothelioma are two different types of cancer that can affect the lungs. Although they have some similarities, there are key differences between the two:

  1. Location: Lung cancer develops inside the lungs, while mesothelioma develops in the lining around the lungs (the pleura).
  2. Causes: Both lung cancer and mesothelioma can be caused by asbestos exposure. However, lung cancer is more commonly caused by smoking and environmental exposure, while mesothelioma is almost always caused by asbestos.
  3. Symptoms: Both diseases can cause symptoms such as chest pain, coughing, difficulty breathing, fatigue, and weight loss.
  4. Diagnosis: Diagnosing mesothelioma and lung cancer requires a doctor to perform a biopsy. A CT or PET scan alone is unreliable for differentiating between the two.
  5. Treatment: Lung cancer treatments differ from mesothelioma treatments because the two cancers are not the same. However, both cancers commonly combine individual treatments into one multimodal therapy.
  6. Growth Pattern: Lung cancer typically grows in individual masses with defined boundaries, while mesothelioma tends to start as small nodule tumors that are scattered in the mesothelial lining and eventually grow together, forming a sheath-like tumor that surrounds the lungs or other organs.

Accurate diagnosis and proper treatment depend on understanding the differences between lung cancer and mesothelioma. It is crucial to consult with a specialist to determine the correct diagnosis and the best course of treatment for each patient.

Comparative Table: Lung Cancer vs Mesothelioma

Here is a table summarizing the differences between lung cancer and mesothelioma:

Feature Lung Cancer Mesothelioma
Formation Develops inside the lungs Develops on the lung's outer lining (pleura)
Causes Multiple causes, including smoking and asbestos exposure Almost always caused by asbestos exposure
Types Adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and small cell lung cancer Epithelioid, biphasic, and sarcomatoid
Symptoms Chest pain, coughing, difficulty breathing, fatigue, and weight loss Chest pain, coughing, difficulty breathing, fatigue, and weight loss
Diagnosis Biopsies, blood tests, chest X-rays, CT scans, MRI scans, PET scans, and sputum cytology Biopsies, blood tests, chest X-rays, CT scans, MRI scans, PET scans, and thoracentesis
Treatment Surgery, chemotherapy, radiation therapy, and targeted therapy Surgery, chemotherapy, and radiation therapy, with limited options due to rarity
Prevalence Lung cancer is the second-most common cancer in the U.S., with about 222,500 new cases reported annually Mesothelioma is a rare cancer, with about 2,800 cases reported across all types

It is important to note that lung cancer and mesothelioma share some similarities, such as causing chest pain, coughing, difficulty breathing, fatigue, and weight loss. However, they differ in their formation, causes, types, and treatment approaches.