What is the Difference Between Vasculogenesis and Angiogenesis?

Vasculogenesis and angiogenesis are both processes involved in the formation of blood vessels, but they differ in their mechanisms and temporal occurrence:

• Vasculogenesis refers to the in situ differentiation and growth of blood vessels from mesodermal angiogenesis involves two distinct mechanisms: endothelial sprouting and intussusceptive microvascular growth (IMG).
• Endothelial sprouting is based on endothelial cell migration, proliferation, and tube formation.
• IMG divides existing vessel lumens by forming and inserting tissue folds and columns.

Vasculogenesis is mainly observed during embryonic development, while angiogenesis can occur in adults during the healing of injured tissues, organ growth, or pregnancy.

In summary, vasculogenesis is the formation of new blood vessels from mesodermal angiogenesis is the sprouting and remodeling of new blood vessels from existing ones.

Comparative Table: Vasculogenesis vs Angiogenesis

Here is a table comparing vasculogenesis and angiogenesis:

In summary, vasculogenesis is the process of forming new blood vessels from endothelial stem cells or angioblasts, typically occurring during embryonic development and in certain adult situations. Angiogenesis, on the other hand, is the formation of new blood vessels from pre-existing ones, often in response to injury or diseases such as cancer.